Antibacterial hydrogel therapy for eradication of wound associated polymicrobial biofilms

نویسندگان

چکیده

The recalcitrance of bacterial biofilms to current antimicrobials has presented a major cause clinical recurrence wound infections. These biofilm-associated infections are often present in polymicrobial nature associated with the presence Pseudomonas aeruginosa and Staphylococcus aureus creating large heterogeneity that shares common resistance making pathogen eradication extremely challenging. In this study, we overcome intrinsic biofilm barriers by delivering ultrasmall-sized silver nanoparticles (AgNP) using smart hydrogel system allows slow sustained release ions mediating successful accumulation penetration biofilms. antibiofilm efficacy AgNP was assessed ex vivo porcine Treatment resulted significant dispersion early mature biofilms, 2–5-log reduction bacteria compared untreated controls. This approach overcomes enhanced tolerance combined benefits delivery properties ultrasmall AgNPs ensure complete destruction elimination.

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ژورنال

عنوان ژورنال: Microbiology Australia

سال: 2023

ISSN: ['1324-4272', '2201-9189']

DOI: https://doi.org/10.1071/ma23029